STAFF BOARD
Article
CHAIRMAN
Maruxa Hernández Corredoira
EDITOR IN CHIEF
Manuela Velázquez Prieto
Tomás Casasín Edo
MARKETING MANAGER
EDITORIAL BOARD
María B. Badía Tahull
Lluís Campins Bernadas
Juan Carlos Juárez Giménez
Carles Quiñones Ribas
Volume 23 - Issue 1, January-March 2021
SHORT REPORTS
PERIOSTITIS AFTER PROLONGED USE OF ALPROSTADIL IN NEWBORNS WITH CONGENITAL CYANOTIC HEART DISEASE: CASE REPORTS
DANTAS GOMES ANA BEATRIZ, MEDEIROS FERNANDES FLÁVIA EVELYN, ALVES DA SILVA JÁRDILA RAVANA, CIRYLLO SILVA NOYA DANILLO JOSÉ, DE MELO MAIA BEZERRA ANA FLÁVIA, MACIEL NETO JOSÉ JORGE, RANDALL MARTINS RAND


Objective: Describe two cases of periostitis following prolonged use of alprostadil, a rare and potentially serious complication of an adverse drug reaction. Case description: Two term newborns diagnosed with cyanotic congenital heart disease. In use of alprostadil for approximately 20 days, edema in the lower limbs and hyperthermia were noted. Radiological evaluation showed periostitis in long bones in both cases. Comments: Periostitis is one of the rare adverse reactions to the use of alprostadil. The most frequent complication is the formation of limb edema, accompanied by muscle stiffness and pain. The most frequently affected bones are the long bones, ribs, shoulder blades and clavicles. The prognosis is generally good, disappearing within six to twelve months after drug withdrawal, apparently with no consequences for future bone growth. However, the two cases described have died.

ALPROSTADIL – DRUG-RELATED SIDE EFF ECTS AND ADVERSE REACTIONS – NEWBORN – PERIOSTITIS



Fill out the form below to buy this article

Name and surname:

DNI/NIF ID/VAT IDENTIFICATION No.:

Contact Email:

Phone:

Address:

Zip code:

City:

Province:

Country:

*I have read and accept the privacy policy
Price : 30,25