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Maruxa Hernández Corredoira
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Manuela Velázquez Prieto
Tomás Casasín Edo
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María B. Badía Tahull
Lluís Campins Bernadas
Juan Carlos Juárez Giménez
Carles Quiñones Ribas
Volume 22 - Issue 2, April-June 2020
ORIGINAL
UNIFICATION OF THE PREPARATION OF METHOTREXATE, CYTARABINE AND HYDROCORTISONE INTRATHECAL IN A SINGLE SOLUTION
LÓPEZ MONTERO ELENA, MOSQUERA TORRE ALICIA, TOURÍS LORES MANUEL, BERNÁRDEZ FERRÁN BEATRIZ, ZARRA FERRO IRENE


In our unit, the solutions of the three drugs administrated intrathecally, metho- trexate,
cytarabine and hydrocortisone, were prepared separately and differently depending on if it will be
administrated for pediatric or adult population. With the aim of unifying the preparations and
because the administration of these agents could be greatly facilitated if all three agents were
combined in a single solution, we evaluated some pharmaceutical aspects such as pH and osmolality
of com- bined preparations and the separated preparations.
It was concluded that the preparation of a single solution had better charac- teristics of
osmolality and pH for intrathecal administration than the separated preparations.

CYTARABINE – INTRAATTHHEECCCAALL – METHOTTRREEXXAATE – OSMOLALITY – PH



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