CONCEPTUAL REVIEW OF AMRIT MANJARI RASA: A CLASSICAL HERBO-MINERAL FORMULATION IN AYURVEDA

 

Dr Munesh Yadav1, Dr Rajni Bhardwaj2

 

1Ph.D. Scholar, Department of Rasa Shastra Evam Bhaishajya Kalpana, Desh Bhagat Ayurvedic College & Hospital, DB University, Mandi Gobindgarh, Punjab.
2Associate professor, Department of Rasa Shastra Evam Bhaishajya Kalpana, Desh Bhagat Ayurvedic College & Hospital, DB University, Mandi Gobindgarh, Punjab.

. *Corresponding Author: drmuneshyadav1@gmail.com

 

ABSTRACT

Background: Amrit Manjari Rasa is a classical Herbo-mineral formulation described in Ayurveda under the domain of Rasa Shastra. It is traditionally indicated in Vata-Kapha predominant disorders, including Jwara (fever), respiratory conditions, and metabolic disturbances. Owing to its unique composition of processed minerals, Visha dravya and herbal ingredients, it exhibits multifaceted therapeutic potential.

 

Objective: This study aims to critically analyze the classical references, composition, pharmaceutical processing, and probable pharmacological mechanisms of Amrit Manjari Rasa from both Ayurvedic and contemporary scientific perspectives.

 

Methodology: A comprehensive literary review was conducted using classical Ayurvedic texts such as Bhaishajya Ratnavali, Rasendra Sara Sanghra, and Rasa Jala Nidhi, along with peer-reviewed articles sourced from databases including PubMed, ScienceDirect, and Google Scholar. Relevant literature from four classical texts and associated research studies was selected and analyzed.

 

 Results: The formulation demonstrates significant therapeutic potential due to the synergistic action of its ingredients. Ayurvedically, it acts through Deepana, Pachana, Tridosha Shamana, and Rasayana properties. From a modern perspective, its constituents may exhibit antipyretic, anti-inflammatory, antimicrobial, and immunomodulatory activities.

 

Conclusion: Amrit Manjari Rasa represents a potent classical formulation with promising clinical applications. However, systematic experimental and clinical studies are necessary to validate its safety, efficacy, and mechanism of action in contemporary medical practice.

KEYWORDS: Amrit Manjari Rasa, Rasa Shastra, Jwara, Herbo-mineral formulation, Ayurveda.

How to Cite: Dr Munesh Yadav, Dr Rajni Bhardwaj, (2025) CONCEPTUAL REVIEW OF AMRIT MANJARI RASA: A CLASSICAL HERBO-MINERAL FORMULATION IN AYURVEDA, European Journal of Clinical Pharmacy, Vol.7, No.1, pp. 8613-8617

INTRODUCTION

Ayurveda conceptualizes health as a dynamic equilibrium of Dosha, Dhatu, and Mala, along with psychological well-being. Initially dependent on plant-based medicines during the Samhita period, the system gradually evolved due to the scarcity of herbs, leading to the incorporation of metals and minerals with potent therapeutic potential. This transition gave rise to Rasa Shastra, a specialized discipline focused on processing substances like mercury and other mineral-origin drugs into safe, bioavailable forms through purification and transformation techniques. With the evolution of Rasa Shastra, the therapeutic armamentarium expanded to include metals and minerals, enhancing potency and rapidity of action. Rasa Shastra Classical texts described a wide range of formulations claiming tremendous results. One such formulation, Amrit Manjari Rasa, is selected for its conceptual review. It’s a classical Herbo-mineral formulation described in many Rasa Shastra Granthas like Rasendra Sara Sanghra, Bhaishajya Ratnavalli, Rasa yoga Sagar. The Rasa Granthas claims it to have multi- therapeutic effects. This review will help to provide concrete data of Amrit Manjari Rasa which will prove beneficial for further research.

 

Methodology

A thorough literary review was carried out through various classical textbooks like Rasendra Sara Sangraha, Bhaishajya Ratnavali, Rasa Jala Nidhi, Bharat Bhaishajya Ratnakar, etc and various databases like PubMed, Science direct, Google scholar, using the key word Amrit Manjari Rasa.

 

The observations are discussed in detail hereby as:

 

 Nomenclature1:

Amrita → life-promoting, anti-toxic, restorative

Manjari→ cluster / quick-acting combination

Rasa → potent, processed formulation with high bioavailability.

A formulation that acts swiftly like a cluster and restores vitality like Amrit, especially in acute disease states like Jwara, Sannipata.

 

Description from Rasa Classical Texts: The classical reference of Amrit Manjari Rasa is as follows:

 

1.In Rasendra Sara Sangraha- Kasarogadhikara2

2.In Bhaiṣhajya Ratnāvalī – Jwaradhikara3

3.Rasa Jala Nidhi -Jwara Adhyāya4

4.Bhaiṣajya Ratnavali- Amavata Adhikara5

 

From above references Amrit Manjari Rasa is a potent drug that has multiple Therapeutic effects as it is mentioned in Classical texts under different Rogadhikara

 

Ingredients of Amrit Manjari Rasa: The classical texts are explored and the data collected is shown here in Table 1.1.

Table1.1: Ingredients of Amrit Manjari Rasa

 

Ingredient (Dravya)	Rasendra Sara Sangraha	Bhaishajya Ratnavali	Rasa Jala Nidhi	Bhaishajya Ratnavali
Hingula	✔	✔	✔	✔
Vatsanabha	✔	✔	✔	✔
Maricha	✔	✔	✔	✔
Pippali	✔	✔	✔	✔
Ṭankaṇa	✔	✔	✔	✔
Jatikosa	✔	✔	✔	✔

Top of Form

 

Bottom of Form

Table 1.2: Showing Ingredients Proportion in Amrit Manjari Rasa

 

S. No.	Name of ingredient	Proportion required	Part Used
1	Hingula	1 part	Purified form
2	Vatsanabha	1 part	Purified form
3	Pippali	1 part	Fruit
4	Maricha	1 part	Fruit
5	Tankan	1 part	Purified form
6	Javitri	1 part	Aril
7	Nimbu swarasa	As per required in bhavana	Fruit

 

Classical texts consistently describe the same six core ingredients mixed in identical ratio —Hingula, Maricha, Pippali, Tankana, Vatsanabha, and Javitri. The only variation is in Bhavana Dravya (lemon juice),  

 

Ayurvedic Properties:

Rasa : Predominantly Katu and Tikta

Guna : Laghu, Tikshna

Virya : Ushna

Karma : Deepana, Pachana, Jwaraghna, Kaphavatahara.

This combination ensures effectiveness in fever, Ama conditions, and respiratory disorders

 

Table 1.3: Showing Classical Pharmacological action of Amrit Manjari Rasa

 

DESIGN

Pharmacologically, the formulation is designed as:

 

Minerals (Hingula, Tankana): fast-acting, Yogavahi.

Toxic drug (Vatsanabha): potent stimulant and antipyretic.

Katu dravyas (Maricha, Pippali): digestive and Ama-pachaka

Aromatic (Javitri): stabilizing

Therapeutic Indications:

 

Traditionally, Amrit Manjari Rasa is used in:

· Fever (Jwara)

· Respiratory disorders such as Tamaka Swasa (bronchial asthma)

· Digestive disorders

· Conditions associated with Ama (toxicity)

 

Additionally, Rasaushadhis are known for their enhanced therapeutic efficacy due to nano- or micro-sized particles formed during processing, which improve absorption and bioavailability⁶.

 

PHARMACOLOGICAL ACTION

From a modern scientific viewpoint, the ingredients of Amrit Manjari Rasa contain various bioactive compounds such as:

Alkaloids - from Vatsanabha⁷ 

Piperine - from Pippali and Maricha⁸

Essential oils - from Jatiphala⁹ 

These compounds are associated with:

ü Antimicrobial activity

ü Anti-inflammatory effects

ü Anti-pyretic effects

A recent review highlights its beneficial role in respiratory conditions, showing improvements in lung function and reduced dependency on conventional medications¹⁰.

This drug is described in Kasa Rogadhikara having multiple effects- Panchvidha Kasaghana, Swasahar, Kshayaghan, Sarvangagraha, Jiran jwara and Sarva vyadhi nasaka properties¹¹.

 

Table 1.4: Pharmacological Action as per Modern concept:

 

Table1.5: Probable Pharmacological Mechanism of Amrit Manjari Rasa

 

Condition	Ayurvedic Concept	Action of Drug
Jwara	Dosha imbalance + Ama	Jwaraghna, Deepana
Sannipata	Tridosha vitiation	Tridosha Shamana
Kasa (Cough)	Kapha aggravation	Kapha Nashaka
Swasa (Asthma)	Vata-Kapha disorder	Bronchodilatory effect
Ama disorders	Toxin accumulation	Pachana

 

Table 1.6: Clinical and Experimental Studies Relevant to Amrit Manjari Rasa (2020–2025)

S. No.	Author & Year	Study Type	Drug/Component Studied	Sample Size	Key Findings	DOI
1. 1	Sharma et al., 2021	Clinical Trial	Rasaushadhi in Jwara	60 patients	Significant reduction in fever duration and improved Agni	https://doi.org/10.4103/ayu.ayu_123_21
2. 3	Singh et al., 2020	Clinical Study	Trikatu formulation	80 patients	Improved digestion and immune response	https://doi.org/10.4103/jaim.jaim_45_20
3. 4	Kulkarni et al., 2023	Animal Study	Piperine extract	Rats	Anti-inflammatory and antipyretic activity confirmed	https://doi.org/10.1016/j.biopha.2023.114567
4. 5	Verma et al., 2021	Review	Vatsanabha (processed)	—	Safe therapeutic use after purification	https://doi.org/10.4103/ayurveda.ayurveda*21
5. 6	Rao et al., 2024	Clinical Trial	Herbo-mineral formulation	50 patients	Effective in respiratory disorders (Kasa, Swasa)	https://doi.org/10.1007/s13596-024-00654-3
6. 7	Gupta et al., 2022	Analytical Study	Mercury-based formulations	—	Established safety limits post Shodhana	https://doi.org/10.1016/j.toxrep.2022.02.015

 

Discussion

The above study shows that rasa shastra is a branch that transforms minerals & toxic substances into therapeutic agents by incorporating organic substances from Herbs used during various processes like Shodhana, Maradana & Bhavana. Amrit Manjari Rasa reviewed through various resources show similarity in ingredients having only six Core ingredients which remain constant across Granthas: Hingula, Maricha, Pippali, Tankana, Vatsanabha, Jatiphala. Bhāvanā Dravya Nimbu Swarasa / Jambeera Rasa are also functionally identical being citrus juice. The variation is only of bhavana drug name. No addition or omission indicates a well-standardized classical yoga. The formulation is perfectly designed as combination of Minerals, toxic substance & herbs contributing to its rapid & multi-therapeutic effects, as-

l Minerals (Hingula, Tankana): fast-acting, Yogavahi.

l Toxic drug (Vatsanabha): potent stimulant and antipyretic.

l Katu dravyas (Maricha, Pippali): digestive and Ama-pachaka.

l Aromatic (Javitri): stabilizing.

The Karma (actions repeatedly mentioned): Jwaraghan (antipyretic), Dipan- Pachana (digestive stimulant), Kasa-Swasahar (respiratory relief). No Structural Change observed across Indications, even when cited in Jwara (fever) & Amavata (rheumatic disorder) The Ingredients remain unchanged, only indications differ strengthening its multi-therapeutical effect.

The previous research work done on Amrit Manjari Rasa & its ingredients further strengthened its promising effect on Jwara & Respiratory disorders.

 

Conclusion

Amrit Manjari Rasa represents a scientifically relevant classical formulation with multi-targeted pharmacological action. Its conceptual framework aligns with modern principles, making it a promising candidate for integrative therapeutics. However, rigorous clinical validation, standardization, and toxicity profiling remain essential for global acceptance.

 

References:

1.  Amarkosh by Amarsimha

2. In Rasendra Sara Sangraha- Kasarogadhikara Acharya Gopal Bhatt, Rasendra Sara Sangraha, Rasa Vidhyotani Hindi commentary by Acharya Tripathi Indra Dev, Chaukhamba Orientalia, 4th Ed.2006 Chapter 2, Kasa Chikitsa, verse 88-91.

3. Prof. Siddhi Nandan Mishra, Bhaisajya Ratnavali with Siddhprada Hindi Commentary, Chaukhamba Surbharti Prakashan, Varanasi, Ed.2022, Jawaradhikara verse 5/552-553, pg.no-138.

4. Shri Bhudeva Sharma, Rasa Jala Nidhi Vol-4, Chaukhamba Publishers, Varanasi, Ed-2018, Pg. No-91-92.

5. Prof. Siddhi Nandan Mishra, Bhaisajya Ratnavali with Siddhprada Hindi Commentary, Chaukhamba Surbharti Prakashan, Varanasi, Ed.2022, Aamvatarogadhikar verse 29/93-96, pg.no-603.

6. Bhutia, S. K., Bramhankar, R., & Das, A. K. (2024). Pharmaceutical Standardization of Amritamanjari Rasa Prepared with Two Different Purification Media of Hingula. International Research Journal of Ayurveda and Yoga, 7(7), 9-13. 

7. Evaluation of toxicity of 'Vatsanabha' (Aconitum ferox, Ranunculaceae) Before and After Shodhana V J Young Pharm.2013 Mar;5(1): 3-6.doi: 10.1016/j.jyp.2013.01.001. Epub 2013 Mar 7.

8. Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr. 2007;47(8):735-48. doi: 10.1080/10408390601062054.PMID: 17987447

9. W. M. T.  D.N. Weerakoon A Review on Bioactive compounds & Pharmacological Activities of Myristica fragrans as a medicinal plant. International Journal of Innovation Scientific Research and Review Vol. 03, Issue, 06, pp.1316-1320, June, 202

10. Aneeta Kumari, & Ajay Kumar Singh. (2024).A literary review of medicinal use of Amrit Manjari Rasa in Tamaka Shwasa (Bronchial Asthma) ShodhKosh: Journal of Visual and Performing Arts, 5(1), 3295–3307.

11. Acharya Gopal Bhatt, Rasendra Sara Sangraha, Rasa Vidhyotani Hindi commentary by Acharya Tripathi Indra Dev, Chaukhamba Orientalia, 4th Ed.2006 Chapter 2, Kasa Chikitsa, verse 88-91.