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Volume 22 - Issue 1, January-March 2020
SHORT REPORTS
EVALUATION OF THE CONVENIENCE OF USING STERILE SEALS IN THE PREPARATION OF INTRAVENOUS COMPOUNDS IN THE HOSPITAL PHARMACY SERVICES
BONILLA PEÑARRUBIA RODRIGO, RODRÍGUEZ LUCENA FRANCISCO JOSÉ, CANO CUENCA NIEVES, LAS HERAS GUERRERO HÉCTOR, CANDELA FAJARDO ANA, DEVESA GARCÍA CARLOS, ARROYO DOMINGO ELENA


Introduction: The Guidance on good manufacturing practices of pharmaceutical products in hospital pharmacy services recommend the use of resealable vial closures, though there is no reference regarding the sealing of the elastomer of the prepared compound and no studies on microbiological penetrability and sterility
of the solution once the injection site is pierced. This research was performed to assess the aforementioned penetrability.
Method: Experimental study was carried out in the pharmacy service of a secondary hospital at two different intervals, and reproduced. The injection site was seeded with E Coli. The procedure was performed on two groups of six infusion bags after consecutive punctures, and sent to the microbiology service for
microbiological control at 24 and 72 h.
Results: No microbiological growth was identified in either preparations of both experimental groups.
Conclusions: These data made us consider on the utilization of these seals of the prepared compounds in pharmacy, as well as to conduct further studies in this regard.

GOOD PRACTICES – MICROBIOLOGYCAL CONTAMINATIONS – STERIL SEAL



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