|Former: Atención Farmacéutica|
|Journal edited by Rasgo Editorial since 1983|
Virginia Hernández Corredoira
EDITOR IN CHIEF
Manuela Velázquez Prieto
Jaime E. Poquet Jornet
Ramón Jódar Masanés
Lluís Campins Bernadas
Tomás Casasín Edo
Juan Carlos Juárez Giménez
Carles Quiñones Ribas
Volume 22 - Issue 1, January-March 2020
EXPERIENCE WITH AMPHOTERICIN B DEOXYCHOLATE LOADED BONE CEMENT IN STAGED TREATMENT OF OSTEOARTICULAR INFECTIONS
GÓMEZ GANDA LAURA, CORONA PÉREZ-CARDONA PABLO, GARCÍA ORTEGA PATRICIA, LARROSA GARCÍA MARÍA, AMAT MATEU CARLOS, CARRERA CALDERER LUIS, JUÁREZ GIMÉNEZ JUAN CARLOS
The osteoarticular infections arena can include osteomyelitis, septic arthritis, fracture-related infections and periprostheticjoint infections, the latestone of the most feared postsurgical complication after joint replacement surgery. Fungal infections are much less frequent than bacterial infections; however, they have,
theoretically, a poorer prognosis. The most accepted treatment for any musculoskeletal fungal infection is a staged surgical approach, which implies, apart from surgical debridement the administration of antibiotics and antifungals, bothsystemically and locally thought drug-loaded bone cement used to conform and/or fix bone-cement spacers, bone substitutes or auto/allografts.
Two cases are presented in this paper. The first patient sustaineda chronic osteomyelitis and the second a delayedhip periprostheticjoint infection; the pathogens were a Candida parapsilopsis and Candida albicans respectively. Both patients underwent a surgical procedure using high dosesof local amphotericin B
deoxycholate powder (Amphotericin B for injection USP ®), together with vancomycin and gentamicin during the first step of the procedure; once the infection was considered controlled a secondary reconstructive procedure was performed.
Both patients had an adequate clinical evolution, with neither renal impairment nor other antifungal-related adverse events. To this day, patients have not suffered relapse of the fungal infection.
AMPHOTERICIN B DEOXYCHOLATE – BONE CEMENT – FUNGAL PERIPROSTHETICINFECTION