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Volume 21 - Issue 4, October-December 2019
ORIGINAL
CORRELATION AND ASSOCIATION BETWEEN INDEPENDENT VARIABLES AND THE PRESENCE OF ADVERSE REACTIONS AS A DEPENDENT VARIABLE IN CANCER PATIENTS
KUMAR JYOTI, GUDHOOR MANJULA, GANACHARI MADIWALAYYA SHIVAKANTAYYA


Background: Cancer is a rampant disease which can be cured or managed or prevented
with the assistance of a health care team. Along with the assistance, there
are certain cocktail of elements that play a vital role in achieving positive therapeutic
outcome in cancer patients. Medication adherence (chemotherapy as well
as supportive therapy), length of hospital stay, patient education, social economic
status, marital status was few among the innumerable elements that can be specified. These factors are linked directly/indirectly to adverse drug reactions (ADR),
but there is hardly few/no evidence to prove the extent relationship among these
parameters with ADR as a dependent variable. The need of hour is to quantify the
extent relationship of these factors in order to optimize the therapy according to
the variation in the supporting factors affecting the medication therapeutic outcome
in the cancer survivors.

Purpose: To quantify the correlation and association of length of stay, medication
adherence (chemotherapy and supportive therapy) and patient education with
adverse drug reaction in cancer patients receiving chemotherapy.

Procedure: A 6-months prospective-interventional study was conducted in Oncology
department of KLES Dr. Prabhakar Kore Hospital and Medical Research
Centre, Belgaum, Karnataka, India. Cancer patients receiving chemotherapy were
Screened; furthermore, 90 patients were recruited who fit to the inclusion criteria.
All the variables were collected in validated data collection form. The results
were interpreted using Spearman correlation coefficient and regression analysis.

Main findings: Among 90 recruited patients, significant correlation was observed
between ADR with length of hospital stay, chemotherapy and supportive
adherence and patient education. Simultaneously, the regression analysis shows
that with every unit increase in the four respective independent variables; ADR:
the dependent variable increases significantly at p ˂0.05.

Conclusion: This study concludes that substantial pharmacist efforts towards the
pharmaceutical care in the oncology clinical practice which highlights the gist of
quantification of the association of the essential elements of patient care helps to
improve the therapeutic outcome by revamping the adherence to the therapy by mitigating
the level of adverse drug reactions faced by the cancer patients.

ADVERSE DRUG REACTIONS – CANCER – CHEMOTHERAPY –LENGTH OF HOSPITAL STAY – MEDICATION ADHERENCE – PATIENT EDUCATION



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