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Volume 21 - Issue 2, March-April 2019
ORIGINAL
IMPACT OF PATIENT PLATELET COUNT, AGE AND GENDER ON ASPIRIN EFFICACY IN PREVENTION OF ISCHEMIC STROKE RECURRENCE
RAHIMI SADEGH, ALMASI-DOOGHAEE MOSTAFA, FALAHAT FARZAN, DARVISH ARASH, MOGHADDASI MEHDI, RAHIMI HAMIDREZA


Background: Stroke is the first leading cause of disability worldwide. Aspirin is used as secondary prevention in ischemic stroke. We evaluated the possible impact of patient platelet count, age and sex on aspirin efficacy as secondary prevention for ischemic stroke.

Method: A retrospective cohort study was conducted on ischemic stroke or TIA patients. All data on admission and discharge were recorded. We followed all patients for TIA, stroke and other problems up to one year. The exclusion criteria were therapy with any other antiplatelet/anticoagulant medication beside aspirin before stroke onset and lack of follow-up data. Finally, four balanced age groups under 55, 55-70, 70-80, and over 80 years were defined.

Results: Of the 231 patients, 122 patients (88%) met the criteria. On follow-up, 2.6% of the cases reported a new Stroke, 4.6% of the cases experienced TIA and 6.49% admitted to hospital due to vascular diseases. In four age groups, mean ±SD of admission platelet level were 226.255 ±60.5, 228.39 ±79.8, 202.17 ±68.3 and 199.55 ±67.4 respectively. Aspirin had no significant effects on patients over 80 years old with platelet count below 155 × 103/mm3.

Conclusions: We found that aspirin had no significant effect on patients over 80 years with platelet below 155 × 103/mm3. On the other hand, aspirin reduces stroke recurrence, with no significant gender related difference. In order to compare the efficacy of other medications besides aspirin, further investigations are required.

AGE – ASPIRIN – BLOOD PLATELET COUNT – GENDER – ISCHEMIC STROKE



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