European Journal of Clinical Pharmacy

Volume 20 - Issue 2, March-April 2018

REVIEWS

DIRECT ORAL ANTICOAGULANTS IN ATRIAL FIBRILLATION

GÓMEZ HERRERO DIEGO, CARRERA HUESO FRANCISCO JAVIER, POQUET JORNET JAIME EDUARDO, VILA MIRALLES ROCÍO, RAMON BARRIOS MARÍA AUXILIADORA, SANJUAN CERVERO RAFAEL

Oral anticoagulants are recommended for the prevention of stroke in patients with non-valvular atrial fibrillation. Vitamin K antagonists (VKA) have been used for decades for the treatment and prophylaxis of thromboembolic events. However the direct oral anticoagulants (DOAC), the direct thrombin inhibitor dabigatran and the factor Xa activated inhibitor, apixaban, rivaroxaban and edoxaban, have shown superior safety and efficacy in clinical trials, and are presented as a safe, effective and simple alternative to fixed dose administered. Despite the lack of precise laboratory tests, the degree of anticoagulation cannot be quantified, and are influenced by the changes in drug concentrations during the dosing interval, and also the potential drug interactions and lack of antidote, make the selection of appropriate anticoagulant a clinical challenge.

APIXABAN – ATRIAL FIBRILLATION – DABIGATRAN ETEXILATE – EDOXABAN – RIVAROXABAN – STROKE

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