STAFF BOARD
Article
CHAIRMAN
Manuela Velázquez Prieto
EDITOR IN CHIEF
Jaime E. Poquet Jornet
MARKETING MANAGER
Margarita Pamplona
EDITORIAL BOARD
Tomás Casasín Edo
Virginia Hernández Corredoira
Ramón Jódar Masanés
Juan Carlos Juárez Giménez
Volume 18 - Issue 5, September-October 2016
SHORT REPORTS
CUTANEOUS LUPUS ERYTHEMATOSUS INDUCED BY INFLIXIMAB IN PATIENT WITH CROH N’S DISEASE. A CASE REPORT
CID CONDE LUCIA, SILVEIRA CANCELA DOSINDA, FERNÁNDEZ GONZÁLEZ MARÍA PERFECTA


Introduction: Drug-Induced Lupus (DIL) or lupus-like syndrome is a rare clinical syndrome that appears months or years after exposure to the drug; the development depends on the accumulated dose and being characteristic the temporal association between ingestion of the drug and the appearance of clinical symptoms
and autoantibody; as well as remission of symptoms and decrease in antibody titers following the withdrawal of the same. Infliximab is a chimeric monoclonal antibody indicated for the treatment of severe forms of Crohn’s disease that do not respond to corticosteroids and/or immunosuppressants. We report the case of a patient with Crohn’s disease who presented lupus-like syndrome associated with treatment with infliximab (Remicade®); with a range of occurrence of 3-16 months, serological criteria ANA and non-serological criteria
malar rash. We proceeded to final withdrawal of the drug after re-exposure and appearance of new lesions. She was continued only with azathioprine. The patient progressed favourably with resolution of skin lesions and decreasing doses of oral corticosteroids as well as the occasional application of topical corticosteroids.
Conclusion: The appearance of DIL is an infrequent side effect during treatment with anti-TNF, with an incidence of 0.19 to 0.22% for infliximab, but its administration is not without risk and patients should be closely assessed.

CROHN’S DISEASE – CUTANEOUS LUPUS ERYTHEMATOSUS – INFLIXIMAB



Fill out the form below to buy this article

Name and surname:

DNI/NIF ID/VAT IDENTIFICATION No.:

Contact Email:

Phone:

Address:

Zip code:

City:

Province:

Country:

*I have read and accept the privacy policy
Price : 30,25